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KMID : 0359320170570010047
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Korean Journal of Veterinary Research
2017 Volume.57 No. 1 p.47 ~ p.50
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Dehydroepiandrosterone and cortisol concentrations in the cerebrospinal fluid of dogs
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Mongillo Paolo
Bernardini Marco
Prana Elisa
Balducci Federica
Gabai Gianfranco
Marinelli Lieta
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Abstract
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Concentrations of cortisol, dehydroepiandrosterone and dehydroepiandrosterone-sulfate were measured by performing radioimmunoassay of the cerebrospinal fluid of 68 dogs diagnosed with idiopathic epilepsy or inflammatory, degenerative, or non-neurological disease. No steroid concentration differences were found among diagnoses. Dehydroepiandrosterone and dehydroepiandrosterone-sulfate concentrations were higher in males than in females and dehydroepiandrosterone-sulfate decreased with increasing age. No sex or age effects were observed on cortisol or hormone ratios. Although limited to a relatively small sample, our results show sex- and age-dependent variations in these neurosteroid concentrations in cerebrospinal fluid. The role of such variations in the pathophysiology of the dog brain warrants further investigation.
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KEYWORD
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cerebrospinal fluid, dehydroepiandrosterone, dogs, hydrocortisone, sex
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